Hello, I am looking for someone to write an article on Does Aspirin Affect the Risk of Developing Myocardial Infarction in Patients with Acute Coronary Syndrome. It needs to be at least 2000 words. Those drugs which are selective cyclooxygenase-2 inhibitors and those that are nonselective nonsteroidal anti-inflammatory, have been shown to increase the risk of reinfarction. This study will be hospital based and hopes to collect enough data to find out whether aspirin increases the risk of developing myocardial infarction in patients with acute coronary syndrome. Myocardial infarctions or acute myocardial infarction (MI) is commonly called heart attack and is a serious disease of coronary which occurs due hardening or narrowing of arteries when cholesterol plaque builds up. Blockage of arteries leads to a major reduction of blood supply, consequently causing necrosis (death or damage) of heart muscles (myocardium) or myocardium ischemia as the heart muscles are not served with oxygenated blood for quite some time (Imagins website:The women health resource,Overview of myocardial infarction, 2009).The infarction site depends on which vessels are involved. For example, if blockage occurs in circumflex coronary artery, this leads to lateral MI while blockage of right coronary artery can lead to right sided heart failures (Imagins website:The women health resource,Overview of myocardial infarction, 2009) There are many predisposing factors to the higher number of MI cases. Some of these factors can be controlled while others cannot. These factors are. age, gender, positive family history of MI, high blood pressure, obesity, high levels of cholesterol, lack of physical activity, diabetes, stress, hypertension, increased serum triglycerides, excessive intake of saturated fats, salt and carbohydrates (Ridker et al, 1998. Salim et al, 2004 ). Other risk factors includes, sedentary life, increased homocysteine and C -resistance proteins and use of drugs such as amphetamines and cocaine (Haffner, Seppo, Tapani, Kalevi and Markku, 1998). About 20% of patients with MI have diabetes (Salim et al, 2004).Obesity on its own or in combination with other factors, increases the risk of developing coronary disease (Khandekar, Khurana, Kakrani, Katdare and Inamdar, 2006). The symptoms of MI are. arm, epigastric and chest pain, breath shortness, diaphoresis, clammy skin dizziness, nausea, vomiting, angina frequency, fatigue, presence of pericardial friction rub, systolic murmurs, bradycardia, hypertension, absence of jagular vein distension, activity intolerance, decreased cardiac output, anxiety, among others (Imagins website:The women health resource,Overview of myocardial infarction, 2009) Diagnosis Diagnosis can be achieved through physical examination of symptoms. Other diagnostic tests which can be used are. detection of elevated levels of homocysteine and C- resistance proteins, electrocardiogram, use of cardiac troposin to differentiate between MI and injury of skeletal muscles. This can also be done through looking at the family history to identify if there is positive relationship. Identification of symptoms is important as this may help a clinician to refer the case to more qualified personnel if need be.The clinician should be able to clarify actual and potential health issues and the associated risk factors. Reflective thinking is also an important component during diagnosis.

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